Fifty medical professionals inspired by the Fire Services Department's mascot "Anyone" promoted the necessity of having mobile medical staff rather than first-aid stations along the route.
The group - Medical Anyone - was created by Axel Siu Yuet-chung, president of Hong Kong College of Emergency Medicine.
In the 2015 race, a 24-year-old man died of sudden cardiac arrest.
The group's name hopes to spread the character's message that "anyone can save life."
All members are medical professionals - doctors, nurses and even a university lecturer in emergency medicine - who run long-distance races.
They joined the 10-kilometer race and half and full marathons as participants and wore a label that said "Medical Anyone. Find me for CPR" on the back of their shirts.
"We volunteered to provide immediate assistance to those who collapse during the race," Siu said.
Other runners were encouraged to alert members of the group if they spotted anyone in need of help.
Fortunately, none of the members were needed to save anyone yesterday.
"We were very encouraged that many runners came to us just to express their gratitude. It also makes me feel the compassionate side of Hongkongers," Siu said.
Siu said he looks forward to expanding the group after people with medical qualifications approached him to sign up. But since only 50 labels had been made, there were not enough to be distributed around.
Meanwhile, 61-year-old Chan Kwai-heung, who is blind, finished the 10km race in one hour and 18 minutes.
Chan was led by a volunteer in front of her.
"I am so excited to have finished the race. I feel like I have fulfilled a dream," she said.